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KMID : 0388220130200050323
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Journal of the Korean Rheumatism Association
2013 Volume.20 No. 5 p.323 ~ p.327
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A Case of Scleroderma-like Cutaneous Lesions Induced by Docetaxel in a Patient with Breast Cancer
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Abstract
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Docetaxel, an anti-microtubule agent, has been reported to show cytotoxic effects in solid tumors. Its toxicities also in-clude neutropenia, alopecia, skin reaction, and fluid reten-tion. In this study, we report on a case of a 57-year- old Korean female who presented with rapidly progressive scleroderma-like cutaneous changes in the upper and low-er extremities after administration of docetaxel. Results of the following tests were normal or negative: full blood count, serum urea, creatinine, electrolytes, liver function test, thyroid function test, rheumatoid factor, anti-nuclear antibody, and anti-topoisomerase antibody. No structural abnormalities were noted on esophagogastroduodenoscopy, chest computed tomography, and Doppler ultrasono-graphy. A biopsy of skin from the left calf showed dermal sclerosis. There was no other explanation for the lesion, except a scleroderma-like cutaneous change induced by docetaxel in this Korean female undergoing treatment for breast cancer.
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KEYWORD
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Scleroderma-like cutaneous lesion , Docetaxel, Skin lesion
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